SSD slows epithelialization and increases hypertrophic scar formationĮvaluate healing with NPWT and promogran prisma in chronic wounds NPWT with silver-coated polyurethane sponge accelerates healing even more.Ĭompare healing with SSD versus plain cream for chronic wounds NPWT with polyurethane sponge accelerates the healing of diabetic foot ulcers Silver-containing dressing does not accelerate healing, but improves wound odorĬompare polyurethane to silver-coated polyurethane sponges for NPWT for infected diabetic foot ulcers Silver alginate reduces pain compared to gauze, but does not accelerate healing or decrease costĬompare healing and odor with silver-containing dressing versus plain foam The addition of a silver dressing to polyurethane sponge enhances the antimicrobial activity of NPWTĬompare healing, pain, and cost with silver alginate versus gauze With silver-coated polyurethane NPWT sponge, wound silver level reaches a peak at 5 daysĬompare activity of polyurethane NPWT sponge versus silver dressing and polyurethane NPWT sponge against S. Silver-coated polyurethane NPWT sponge achieves a larger zone of bacterial inhibition than plain polyurethane sponge NPWT with silver-coated polyurethane sponge reduces biofilm even moreĬompare activity of polyurethane NPWT sponge versus silver-coated polyurethane NPWT sponge against S. NPWT with polyurethane sponge reduces biofilm NPWT with silver-coated polyurethane sponge decreases MRSA colony counts more than NPWT with polyurethane spongeĬompare biofilm formation with polyurethane NPWT sponge versus silver-coated polyurethane NPWT sponge Silver ion concentration in wound exudate rises over several daysĮvaluate effectiveness of polyurethane versus silver-coated polyurethane NPWT sponges at reducing MRSA colony counts The questions that we sought to answer were:Įvaluate silver ion elution from silver-coated polyurethane NPWT sponge Our purpose in this study was to evaluate the existing evidence on the use of silver in wound care. 45 It is imperative, therefore, that guidelines be developed on the proper use of silver-containing dressings. 1, 16, 17 Injudicious use of silver-containing dressings can lead to impaired wound healing. While the silver ion has great antimicrobial and bactericidal properties, it is also toxic to fibroblasts when present in high concentration. These novel dressings release silver ions into the wound in a sustained fashion. More recently, dressing with nanocrystalline silver has been developed. Silver sulfadiazine (SSD) is a very widely used silver formulation, especially in burns. The past few decades have seen a renewed interest in silver as a topical antimicrobial agent. 4 For this reason, resistance against the silver ion has only rarely been reported. 2 Ag + binds to DNA, RNA, and various proteins, leading to cell death via multiple mechanisms, 3 such as protein and nucleic acid denaturation, increased membrane permeability, and poisoning of the respiratory chain. 1 While silver metal (Ag) has no medicinal activity, silver ion (Ag +) has a broad antimicrobial spectrum, and is cytotoxic to bacteria, viruses, yeast, and fungi. The usefulness of silver for wound treatment has been known since 69 B.C.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |